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Aminopterin

Cat. No. M9787
Aminopterin Structure
Synonym:

4-Aminofolic acid

Size Price Availability Quantity
5mg USD 53 In stock
10mg USD 96 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia. Aminopterin has anticancer and immunosuppressive activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 440.41
Formula C19H20N8O5
CAS Number 54-62-6
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage -20°C, protect from light, dry, sealed
References

Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues
Andre Rosowsky, et al. J Med Chem. 2004 Dec 30;47(27):6958-63. PMID: 15615544.

Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain
A Rosowsky, et al. J Med Chem. 1991 Apr;34(4):1447-54. PMID: 2016722.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Aminopterin, 4-Aminofolic acid supplier, inhibitors

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