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Aloe-emodin

Cat. No. M4001
Aloe-emodin Structure
Synonym:

AE

Size Price Availability Quantity
10mM*1mL In DMSO USD 100 In stock
100mg USD 90 In stock
500mg USD 220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Aloe-emodin shows significant inhibitory activity against the P-388 leukemia in mice when administered as a suspension in acetone-Tween 80. Aloe-emodin has a specific in vitro and in vivo antineuroectodermal tumor activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 270.24
Formula C15H10O5
CAS Number 481-72-1
Purity >98%
Solubility DMSO 50mg/ml
Storage at -20°C
References

Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.
Pecere T, et al. Cancer Res. 2000 Jun 1;60(11):2800-4. PMID: 10850417.

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Keywords: Aloe-emodin, AE supplier, inhibitors

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