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ATP

Cat. No. M9072
ATP Structure
Synonym:

Adenosine 5'-triphosphate; Triphosphaden

Size Price Availability Quantity
100mg USD 65 In stock
500mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ATP (100-300 µM) inhibits the production of TNF-α by 32±8%, and at 300 µM, the attenuation of TNF-α production is 65±4% in LPS + PHA-stimulated whole blood. ATP (100, 300 µM) increases IL-10 levels by 48±5% (p=0.01) and 62±7%, respectively, in LPS + PHA-stimulated whole blood. ATP does not significantly alter the production of IL-6.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 507.18
Formula C10H16N5O13P3
CAS Number 56-65-5
Purity >98%
Solubility Water: ≥ 80 mg/mL
Storage at -20°C
References

Evaluation of adenosine triphosphate test for cleaning assessment of gastroscopes and the effect on workload in a busy endoscopy center.
Schmitt C, et al. Am J Infect Control. 2018 Oct;46(10):1110-1114. PMID: 29784442.

Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood.
Swennen EL, et al. Eur J Immunol. 2005 Mar;35(3):852-8. PMID: 15719372.

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Keywords: ATP, Adenosine 5'-triphosphate; Triphosphaden supplier, inhibitors

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