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Acacetin

Cat. No. M4584
Acacetin Structure
Synonym:

5,7-Dihydroxy-4'-methoxyflavone

Size Price Availability Quantity
20mg USD 155 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 284.26
Formula C16H12O5
CAS Number 480-44-4
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Acacetin, 5,7-Dihydroxy-4'-methoxyflavone supplier, Potassium Channel, inhibitors

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