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A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.
| Molecular Weight | 271.59 |
| Formula | C8H8Cl2N2S · HCl |
| CAS Number | 22816-60-0 |
| Solubility (25°C) | Water: 2 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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