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6-gingerol

Cat. No. M4121
6-gingerol Structure
Synonym:

(S)-(+)-[6]Gingerol; 6-Gingerol

Size Price Availability Quantity
5mg USD 68  USD68 In stock
10mg USD 95  USD95 In stock
20mg USD 135  USD135 In stock
50mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

[6]-Gingerol is an active substance isolated from ginger and has a variety of biological activities, including anti-cancer, anti-inflammatory and antioxidant.

Chemical Information
Molecular Weight 294.39
Formula C17H26O4
CAS Number 23513-14-6
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yun Tsai, et al. The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

[2] Mu-Keng Hong, et al. 6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway

[3] Feng Zhang, et al. 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation

[4] Roslia Maria Trres de Lima, et al. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review

[5] Jamilah Abusarah, et al. Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis

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Keywords: 6-gingerol, (S)-(+)-[6]Gingerol; 6-Gingerol supplier, AMPK, inhibitors, activators


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