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4-Hydroxytamoxifen

Cat. No. M10252
4-Hydroxytamoxifen Structure
Synonym:

4-OHT

Size Price Availability
5mg USD 74.7  USD83 Out of stock
25mg USD 202.5  USD225 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

4-Hydroxytamoxifen is a selective estrogen receptor modulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 387.51
Formula C26H29NO2
CAS Number 68047-06-3
Purity >99%
Solubility Ethanol 20 mg/mL
DMSO 20 mg/mL
Storage at -20°C
References

4-Hydroxytamoxifen inhibits proliferation of multiple myeloma cells in vitro through down-regulation of c-Myc, up-regulation of p27Kip1, and modulation of Bcl-2 family members
Juliette Gauduchon, et al. Clin Cancer Res. 2005 Mar 15;11(6):2345-54. PMID: 15788686.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 4-Hydroxytamoxifen, 4-OHT supplier, Estrogen Receptor, inhibitors

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