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10074-G5

Cat. No. M2353

10074-G5 Structure
Size Price Availability
25mg USD 190 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

10074-G5 is an inhibitor of c-Myc-Max dimerization (IC50 =146 μM) that operates by binding and stabilizing c-Myc in its monomeric form. 10074-G5 inhibits c-Myc/Max heterodimer formation and its transcriptional activity. 10074-G5 is most efficient in inducing neuronal differentiation and lipid accumulation in MYCN-amplified neuroblastoma cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 332.31
Formula C18H12N4O3
CAS Number 413611-93-5
Purity >99%
Solubility DMSO
Storage at -20°C
References

Discovery of Methyl 4'-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc-Max Dimerization.
Chauhan J, et al. ChemMedChem. 2014 Jun 27. PMID: 24976143.

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors.
Müller I, et al. PloS one. 2014 May 23;9(5):e97285. PMID: 24859015.

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.
Clausen DM, et al. Journal of Pharmacology and Experimental Therapeutics. 2010 Dec;335(3):715-727. PMID: 20801893.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 10074-G5 supplier, c-Myc, inhibitors

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