c-Myc inhibitor 11 is a c-MYC inhibitor (pEC50: 6.4).
| Molecular Weight | 362.43 |
| Formula | C20H22N6O |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Jonathan Welti et al. Cancer Discov. Targeting the p300/CBP Axis in Lethal Prostate Cancer
| Related c-Myc Products |
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| Omomyc
Omomyc is a cell-penetrating peptide derived from the bHLH structural domain of Myc. When expressed in cells, Omomyc inhibits C-Myc-mediated transcription and suppresses cell proliferation.Omomyc competes with C-Myc for binding to Max, resulting in the formation of the Omomyc/Max complex, which competes with the endogenous c-Myc/Max heterodimer and ultimately inhibits transcriptional activation resulting in Myc target genes involved in proliferation and metabolism. |
| MDEG-541
MDEG-541 is a potent MYC-MAX degrader. |
| c-Myc inhibitor 12
c-Myc inhibitor 12 is an inhibitor of c-Myc with a pEC50 of 6.4. |
| m-Se3
m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity. |
| c-Myc inhibitor 10
c-Myc inhibitor 10, a c-Myc inhibitor, exhibits increased cellular potency, consistent with an increase in permeability with methylation of the morpholine nitrogen. |
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