Free shipping on all orders over $ 500


Cat. No. M3924
10-Hydroxycamptothecin Structure

NSC 107124

Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 150 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-Hydroxycamptothecin is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.

Cell Experiment
Cell lines MDA-231, and BT-20 cells
Preparation method Exposing cells to various concentrations of 10-Hydroxycamptothecin for 72 hours. Monitoring cell growth by the standard MTT assay.
Concentrations Dissolved in DMSO, final concentrations ~50 μM
Incubation time 72 hours
Animal Experiment
Animal models BALB/c-nu mice transplanted subcutaneously with Colo 205 cells
Formulation Dissolved in propylene glycol
Dosages ~7.5 mg/kg
Administration Orally once per two days
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 364.35
Formula C20H16N2O5
CAS Number 19685-09-7
Purity >99%
Solubility DMSO 5mg/ml
Storage at -20°C

[Studies on the effects of cucurbit (n = 7) uril on the physicohemical properties and anticancer activity of 10-hydroxycamptothecin].
Lü Y, et al. Guang Pu Xue Yu Guang Pu Fen Xi. 2014 Jun;34(6):1610-4. PMID: 25358173.

Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer.
Ping YH, et al. Oncol Rep. 2006 May;15(5):1273-9. PMID: 16596197.

DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.
Ling YH, et al. Cancer Biochem Biophys. 1990 Jan;11(1):23-30. PMID: 2159843.

Related Topoisomerase Products
Pirarubicin HCl

Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.


Ofloxacin is a synthetic broad-spectrum antimicrobial agent.

Novobiocin Sodium

Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.


Norfloxacin is a broad-spectrum antibiotic.


Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.

Abmole Inhibitor Catalog 2017

Keywords: 10-Hydroxycamptothecin, NSC 107124 supplier, Topoisomerase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.