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Abmole Inhibitor Catalog 2017

5-HT Receptor 5-hydroxytryptamine receptor


Cat.No.  Name Information
M6065 Ziprasidone HCl monohydrate Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
M6064 Ziprasidone HCl Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
M6058 Vortioxetine Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
M6051 Venlafaxine Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
M6050 Venlafaxine HCl Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
M6027 Trazodone Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
M5992 Tegaserod maleate Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit.
M5989 Tandospirone Tandospirone(SM-3997) is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).
M5951 Sarpogrelate HCl Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
M5938 Rizatriptan Benzoate Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.
M5935 Risperidone Risperidone is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.
M5920 Ramosetron HCl Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.
M5884 Pizotifen Pizotifen(Pizotyline) is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
M5861 Paroxetine HCl Paroxetine HCl is an antidepressant drug of the SSRI type.
M5835 Ondansetron Hydrochloride Dihydrate Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors.
M5804 Naftidrofuryl oxalate Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.
M5799 Mosapride Citrate Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
M5798 Mosapride Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
M5754 Loxapine Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
M5660 Fluvoxamine maleate Fluvoxamine Maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.
M5548 Dalasetron Mesylate hydrate Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
M5543 Cyproheptadine hydrochloride sesquihydrate Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine2.
M5542 Cyproheptadine HCl Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.
M5475 Cabergoline Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.
M5466 Blonanserin Blonanserin is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.
M5424 Asenapine maleate Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
M5423 Asenapine Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
M5400 Alosetron Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.
M5214 Lasmiditan Lasmiditan (also known as COL-144 and LY573144) is a high-affinity, highly selective serotonin (5-HT) 5-HT(1F) receptor agonist.
M5130 Cisapride Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. IC50 Value is 0.14 μM (EC50 for 5-HT4 receptor).
M5045 Tianeptine Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo.
M5044 Tianeptine sodium salt Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.
M5022 Almotriptan Malate Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.
M3985 Triptolide Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities.
M3909 Glycyrrhizic acid Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
M3793 Deferitrin Deferitrin is a novel, orally available iron chelator, is in the early stage of clinical development for the treatment of chronic iron overload due to transfusional therapy.
M3791 YM 90K hydrochloride YM 90K hydrochloride is a selective AMPA antagonist with neuro-protective effect. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
M3790 Tasosartan Tasosartan is a selective, potent, orally active and long-acting nonpeptide Angiotensin II type 1 (AT1) receptor antagonist.
M3782 Oxiracetam Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats.
M3772 SB242084 SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively.
M3748 Mestanolone Mestanolone is the 17α-methylated version of dihydrotestosterone (DHT).
M3659 Pimavanserin Pimavanserin is a selective serotonin 5-HT2A inverse agonist.
M3646 Cyclobenzaprine hydrochloride Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant.
M3585 Tropisetron Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
M3583 Urapidil hydrochloride Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.
M3529 BMY 7378 dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
M3524 BRL-15572 BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
M3481 WAY-100635 Maleate WAY 100635 is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.87, exhibits >100-fold selectivity against other 5-HT receptor subtypes and major neurotransmitter receptors.
M3479 Aripiprazole Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
M3472 Naratriptan Naratriptan is a triptan agent that is used for the treatment of migraine headaches.

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