Catalog

5-HT Receptor 5-hydroxytryptamine receptor

Inhibitors

Cat.No.	Name	Information
M9252	YL-0919	YL-0919 is a novel 5-HT1A receptor agonist and selective serotonin reuptake inhibitor.
M9181	8-OH-DPAT	8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A.
M9025	Idalopirdine hydrochloride	Idalopirdine hydrochloride is a potent and selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM.
M9011	PRX-08066	PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist with IC50 of 3.4 nM.
M8955	MIN-101	MIN-101 (Roluperidone) is a novel compound with affinities for 5-HT2A and sigma-2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively.
M8942	GSK163090	GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist.
M8932	Eptapirone	Eptapirone (F11440) is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential.
M8900	TG6-10-1	TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2.
M8856	WAY-100135 dihydrochloride	WAY-100135 dihydrochloride is a potent, selective 5-HT_1A receptor antagonist (IC50 = 15 nM).
M7684	Clozapine N-oxide	Clozapine N-oxide (CNO) is a 5-HT₂ serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
M6065	Ziprasidone HCl monohydrate	Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
M6064	Ziprasidone HCl	Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
M6058	Vortioxetine	Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
M6051	Venlafaxine	Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
M6050	Venlafaxine HCl	Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
M6027	Trazodone	Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
M5992	Tegaserod maleate	Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit.
M5989	Tandospirone	Tandospirone(SM-3997) is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).
M5951	Sarpogrelate HCl	Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
M5938	Rizatriptan Benzoate	Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.
M5935	Risperidone	Risperidone is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.
M5920	Ramosetron HCl	Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.
M5884	Pizotifen	Pizotifen(Pizotyline) is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
M5861	Paroxetine HCl	Paroxetine HCl is an antidepressant drug of the SSRI type.
M5835	Ondansetron Hydrochloride Dihydrate	Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors.
M5804	Naftidrofuryl oxalate	Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.
M5799	Mosapride Citrate	Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
M5798	Mosapride	Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
M5754	Loxapine	Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
M5660	Fluvoxamine maleate	Fluvoxamine Maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.
M5548	Dalasetron Mesylate hydrate	Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
M5543	Cyproheptadine hydrochloride sesquihydrate	Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine2.
M5542	Cyproheptadine HCl	Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.
M5475	Cabergoline	Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.
M5466	Blonanserin	Blonanserin is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.
M5424	Asenapine maleate	Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
M5423	Asenapine	Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
M5400	Alosetron	Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.
M5214	Lasmiditan hydrochloride	Lasmiditan hydrochloride (also known as COL-144 and LY573144) is a high-affinity, highly selective serotonin (5-HT) 5-HT(1F) receptor agonist.
M5130	Cisapride	Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. IC50 Value is 0.14 μM (EC50 for 5-HT4 receptor).
M5045	Tianeptine	Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo.
M5044	Tianeptine sodium salt	Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.
M5022	Almotriptan Malate	Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.
M3985	Triptolide	Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities.
M3909	Glycyrrhizic acid	Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
M3793	Deferitrin	Deferitrin is a novel, orally available iron chelator, is in the early stage of clinical development for the treatment of chronic iron overload due to transfusional therapy.
M3791	YM 90K hydrochloride	YM 90K hydrochloride is a selective AMPA antagonist with neuro-protective effect. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
M3790	Tasosartan	Tasosartan is a selective, potent, orally active and long-acting nonpeptide Angiotensin II type 1 (AT1) receptor antagonist.
M3782	Oxiracetam	Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats.
M3772	SB242084	SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively.

Signaling Pathways

Product Type

5-HT Receptor 5-hydroxytryptamine receptor

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