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Abmole Inhibitor Catalog 2017

5-HT Receptor 5-hydroxytryptamine receptor

Inhibitors

Cat.No.  Name Information
M5475 Cabergoline Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.
M5466 Blonanserin Blonanserin is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.
M5424 Asenapine maleate Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
M5423 Asenapine Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
M5400 Alosetron Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.
M5214 Lasmiditan Lasmiditan (also known as COL-144 and LY573144) is a high-affinity, highly selective serotonin (5-HT) 5-HT(1F) receptor agonist.
M5045 Tianeptine Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo.
M5044 Tianeptine sodium salt Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.
M5022 Almotriptan Malate Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.
M4942 Escitalopram Escitalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
M3985 Triptolide Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities.
M3909 Glycyrrhizic acid Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
M3793 Deferitrin Deferitrin is a novel, orally available iron chelator, is in the early stage of clinical development for the treatment of chronic iron overload due to transfusional therapy.
M3791 YM 90K hydrochloride YM 90K hydrochloride is a selective AMPA antagonist with neuro-protective effect. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
M3790 Tasosartan Tasosartan is a selective, potent, orally active and long-acting nonpeptide Angiotensin II type 1 (AT1) receptor antagonist.
M3782 Oxiracetam Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats.
M3772 SB242084 SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively.
M3748 Mestanolone Mestanolone is the 17α-methylated version of dihydrotestosterone (DHT).
M3659 Pimavanserin Pimavanserin is a selective serotonin 5-HT2A inverse agonist.
M3646 Cyclobenzaprine hydrochloride Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant.
M3585 Tropisetron Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
M3583 Urapidil hydrochloride Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.
M3529 BMY 7378 dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
M3524 BRL-15572 BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
M3481 WAY-100635 Maleate WAY 100635 is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.87, exhibits >100-fold selectivity against other 5-HT receptor subtypes and major neurotransmitter receptors.
M3479 Aripiprazole Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
M3472 Naratriptan Naratriptan is a triptan agent that is used for the treatment of migraine headaches.
M3419 Dapoxetine hydrochloride Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor.
M3417 Clozapine Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.
M3414 Olanzapine Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
M3374 Zolmitriptan Zolmitriptan is a selective serotonin receptor agonist.
M3363 RS-127445 RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
M3239 Ketanserin Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.
M3223 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
M3211 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
M3201 Azasetron hydrochloride Azasetron hydrochloride is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
M3160 Vilazodone Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
M3155 XEN445 XEN445 is a potent and selective EL inhibitor (IC50=0.237 uM) which shows good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
M3127 VUF 10166 VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
M3006 Sertraline hydrochloride Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM.
M3004 Serotonin hydrochloride Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
M3000 SB742457 SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors.
M2999 SB271046 SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
M2966 PRX-08066 Maleic acid PRX-08066 is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model.
M2965 Prucalopride Succinat Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.
M2821 Lorcaserin hydrochloride Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.
M2681 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
M2664 Eletriptan hydrobromide Eletriptan is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.
M2624 Desvenlafaxine Succinate Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
M2623 Desvenlafaxine Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.

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