|M8997||MK-1064||MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for the research of insomnia.|
|M8966||SB-649868||SB-649868 is a selective orally active orexin (OX) receptor antagonist with pKi values of 9.4 and 9.5 at the OX1 and OX2 receptor, respectively.|
|M3796||SB-334867||SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.|
|M3760||TCS-1102||TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).|
|M3710||MK-3697||MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.|
|M3324||SB408124||SB408124 (Tocris-1963) is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.|
|M2272||Suvorexant||Suvorexant (MK-4305) is a potent, selective and orally bioavailable antagonist of OX(1)R and OX(2)R for the treatment of insomnia.|
|M2124||MK-6096||MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R.|
|M1711||Febuxostat||Febuxostat (Uloric) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM.|
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