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Almorexant hydrochloride

Cat. No. M14034
Almorexant hydrochloride Structure
Synonym:

ACT-078573 hydrochloride

Size Price Availability Quantity
5mg USD 158  USD158 In stock
10mg USD 264  USD264 In stock
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Quality Control & Documentation
Biological Activity

Almorexant hydrochloride (ACT 078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

Chemical Information
Molecular Weight 549.02
CAS Number 913358-93-7
Solubility (25°C) DMSO ≥ 46 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michel A Steiner, et al. Neuropsychopharmacology. Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-α1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat

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  Catalog
Abmole Inhibitor Catalog




Keywords: Almorexant hydrochloride, ACT-078573 hydrochloride supplier, OX Receptor, inhibitors, activators


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