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TCS-1102

Cat. No. M3760
TCS-1102 Structure
Size Price Availability Quantity
10mg USD 110 In stock
50mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TCS 1102 is an effective antagonist of the dual orexin receptor. Research indicates that TCS 1102 blocks the ADL-orexin B-mediated locomotion. TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock. Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 470.59
Formula C27H26N4O2S
CAS Number 916141-36-1
Purity >99%
Solubility 100 mM in DMSO
100 mM in Ethanol
Storage at -20°C
References

Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks.
Chen X, et al. Brain Struct Funct. 2014 Nov;219(6):2103-18. PMID: 23955372.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TCS-1102 supplier, OX Receptor, inhibitors

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