Catalog

IκB/IKK Inhibitor of NF-κB/inhibitor of nuclear factor kappa-B kinase

Inhibitors

Cat.No.	Name	Information
M9546	TBK1/IKKε-IN-5	TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
M8970	MLN120B	MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM.
M8961	LY2409881 trihydrochloride	LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM.
M8952	WS6	WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).
M6088	LY2409881	LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.
M5338	PS-1145	PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
M5238	Bardoxolone	Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.
M5197	Amlexanox	Amlexanox is a specific inhibitor of IKKε and TBK1, with an IC50 of approximately 1-2 μM.
M4476	Dehydrocostus-Lactone	Dehydrocostus-lactone (DHE) is a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter.
M4388	Rosmarinic-acid	Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound, it has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.
M2933	PHA-408	PHA-408 is a highly selective and ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.
M2769	IMD 0354	IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.
M2768	IKK-16	IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
M2462	BMS-345541	BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
M2435	Bay 11-7085	BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
M2432	Bardoxolone Methyl	Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.
M2336	BMS-345541 hydrochloride	BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively).
M2300	TPCA-1	TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.
M2060	SC-514	SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM.
M2040	Bay 11-7082	Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM).

Signaling Pathways

Product Type

IκB/IKK Inhibitor of NF-κB/inhibitor of nuclear factor kappa-B kinase

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