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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M8961 | LY2409881 trihydrochloride | LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM. |
| M8952 | WS6 | WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability). |
| M6088 | LY2409881 | LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher. |
| M5338 | PS-1145 | PS-1145 is a specific IKK inhibitor with IC50 of 88 nM. |
| M5238 | Bardoxolone | Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. |
| M5197 | Amlexanox | Amlexanox is a specific inhibitor of IKKε and TBK1. |
| M2933 | PHA-408 | PHA-408 is a highly selective and ATP-competitive IKK-2 inhibitor with IC50 of 40 nM. |
| M2769 | IMD 0354 | IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway. |
| M2768 | IKK-16 | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| M2462 | BMS-345541 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. |
| M2435 | Bay 11-7085 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| M2432 | Bardoxolone Methyl | Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. |
| M2336 | BMS-345541 hydrochloride | BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). |
| M2300 | TPCA-1 | TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| M2060 | SC-514 | SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| M2040 | Bay 11-7082 | Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). |
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