Free shipping on all orders over $ 500

Bardoxolone Methyl

Cat. No. M2432
Bardoxolone Methyl Structure
Synonym:

RTA 402, TP-155, NSC 713200

Size Price Availability Quantity
50mg USD 150 In stock
200mg USD 450 In stock
Bulk Inquiry?

Quality Control
Biological Activity

Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 505.69
Formula C32H43NO4
CAS Number 218600-53-4
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
Related IκB/IKK Products
LY2409881

LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

PS-1145

PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.

Bardoxolone

Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.

Amlexanox

Amlexanox is a specific inhibitor of IKKε and TBK1.

PHA-408

PHA-408 is a highly selective and ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bardoxolone Methyl, RTA 402, TP-155, NSC 713200 supplier, IκB/IKK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.