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Bardoxolone Methyl

Cat. No. M2432
Bardoxolone Methyl Structure

RTA 402, TP-155, NSC 713200

Size Price Availability Quantity
50mg USD 150 In stock
200mg USD 450 In stock
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Quality Control
Biological Activity

Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 505.69
Formula C32H43NO4
CAS Number 218600-53-4
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
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Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.


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Abmole Inhibitor Catalog 2017

Keywords: Bardoxolone Methyl, RTA 402, TP-155, NSC 713200 supplier, IκB/IKK, inhibitors

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