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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M8881 | Ombitasvir | Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. |
| M8880 | Paritaprevir | Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively. |
| M6191 | Velpatasvir | Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication. |
| M3693 | Daclatasvir dihydrochloride | Daclatasvir is a potent hepatitis C virus (HCV) NS5A protein inhibitor with picomolar EC50 value . |
| M3680 | GS-9451 | GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). |
| M3666 | PSI-7977 | PSI-7977 (sofosbuvir) is an investigational nucleotide analog for treatment of chronic HCV infection. |
| M3630 | BILN 2061 | BILN 2061 is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with IC50 of 3.0 nM. |
| M3627 | Vaniprevir | Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. |
| M3624 | Boceprevir | Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection. |
| M3512 | VX-222 | VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. |
| M2727 | GS-9256 | GS-9256 is a novel phosphinic acid derived inhibitor of the HCV NS3/4A protease with IC50 of 4 nM. |
| M2554 | TMC435350 | TMC435350 is a highly specific and potent inhibitor of NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). |
| M2553 | GS-5885 | GS-5885 is an inhibitor of the hepatitis C virus (HCV) NS5A protein and exhibits potent suppression of genotype 1 HCV replicons. |
| M2349 | (R)-Nepicastat hydrochloride | (R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
| M2340 | Asunaprevir | Asunaprevir (BMS-650032) is a novel inhibitor of the hepatitis C virus enzyme serine protease NS3. |
| M2333 | ABT-333 | ABT-333 is a nonnucleoside NS5B polymerase inhibitor for the treatment of HCV infection. |
| M1843 | BMS-790052 | BMS-790052 is a first-in-class, nonstructural protein 5A (NS5A) replication complex inhibitor with an EC50 of 9-50 pM. |
| M1808 | Telaprevir | Telaprevir (VX-950) is a novel hepatitis C virus (HCV) NS3-4A protease inhibitor with IC50 of < 0.2 μM. |
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