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Ombitasvir

Cat. No. M8881
Ombitasvir Structure
Synonym:

ABT-267

Size Price Availability
10mg USD 600 4-7 Days
50mg USD 1800 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir has EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 subgenomic replicons, respectively.

In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 894.11
Formula C50H67N7O8
CAS Number 1258226-87-7
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A.
Krishnan P, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):979-87. PMID: 25451055.

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
DeGoey DA, et al. J Med Chem. 2014 Mar 13;57(5):2047-57. PMID: 24400777.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ombitasvir, ABT-267 supplier, HCV Protease, inhibitors

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