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Ombitasvir

Cat. No. M8881
Ombitasvir Structure
Synonym:

ABT-267

Size Price Availability Quantity
5mg USD 99  USD99 In stock
10mg USD 160  USD160 In stock
25mg USD 330  USD330 In stock
50mg USD 580  USD580 In stock
100mg USD 980  USD980 In stock
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Quality Control & Documentation
Biological Activity

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir has EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 subgenomic replicons, respectively.

In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.

Chemical Information
Molecular Weight 894.11
Formula C50H67N7O8
CAS Number 1258226-87-7
Solubility (25°C) DMSO: ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Krishnan P, et al. Antimicrob Agents Chemother. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A.

[2] DeGoey DA, et al. J Med Chem. Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

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Keywords: Ombitasvir, ABT-267 supplier, HCV Protease, inhibitors, activators


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