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Boceprevir

Cat. No. M3624
Boceprevir Structure
Synonym:

EBP-520, SCH503034

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL In DMSO USD 140 In stock
5mg USD 120 In stock
10mg USD 200 In stock
50mg USD 680 In stock
100mg USD 900 In stock
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Quality Control
Biological Activity

Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection. Boceprevir with pegylated interferon and ribavirin (PegIFN/RBV) enabled improvement in sustained virological response rates of patients with genotype 1 HCV. Boceprevir interacts with immunosuppressive therapy (IT) by inhibiting the cytochrome P450 3A enzyme.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 519.68
Formula C27H45N5O5
CAS Number 394730-60-0
Purity >99%
Solubility DMSO
Storage at -20°C
References

Practical management of boceprevir and immunosuppressive therapy in liver transplant recipients with hepatitis C virus recurrence.
Coilly A, et al. Antimicrob Agents Chemother. 2012 Nov;56(11):5728-34. PMID: 22908172.

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Keywords: Boceprevir, EBP-520, SCH503034 supplier, HCV Protease, inhibitors

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