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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9505 | Compound E | Compound E is a cell-permeable, potent, selective inhibitor of γ-secretase and Notch processing. |
| M9041 | PF-03084014 | PF-03084014 (Nirogacestat) is a potent and selective γ-secretase inhibitor with IC50 of 6.2 nM. |
| M7885 | L-685,458 | L-685,458 is a potent, selective, structurally novel γ-secretase inhibitor; equipotent inhibitor of both Aβ1-42 and Aβ1-40 production. |
| M3619 | Begacestat | Begacestat selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). |
| M3523 | YO-01027 | YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively. |
| M2828 | LY900009 | LY900009 is a potent Notch inhibitor with IC50 of 0.27 nM. |
| M2827 | LY3039478 | LY3039478 is a novel and orally bioavailable inhibitor of Notch-1 intracellular domain (N1ICD) cleavage with IC50 of ~1 nM. |
| M2703 | FLI-06 | FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
| M2277 | Semagacestat | Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. |
| M2172 | LY2811376 | LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM. |
| M2130 | LY-411575 | LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. |
| M2120 | MK-0752 | MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells. |
| M2015 | RO4929097 | RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. |
| M1947 | BMS-708163 | BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). |
| M1746 | DAPT | DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. |
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