Free shipping on all orders over $ 500
Abmole Inhibitor Catalog 2017

Gamma-secretase Gamma-secretase


Cat.No.  Name Information
M9505 Compound E Compound E is a cell-permeable, potent, selective inhibitor of γ-secretase and Notch processing.
M9041 PF-03084014 PF-03084014 (Nirogacestat) is a potent and selective γ-secretase inhibitor with IC50 of 6.2 nM.
M7885 L-685,458 L-685,458 is a potent, selective, structurally novel γ-secretase inhibitor; equipotent inhibitor of both Aβ1-42 and Aβ1-40 production.
M3619 Begacestat Begacestat selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP).
M3523 YO-01027 YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
M2828 LY900009 LY900009 is a potent Notch inhibitor with IC50 of 0.27 nM.
M2827 LY3039478 LY3039478 is a novel and orally bioavailable inhibitor of Notch-1 intracellular domain (N1ICD) cleavage with IC50 of ~1 nM.
M2703 FLI-06 FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
M2277 Semagacestat Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.
M2172 LY2811376 LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM.
M2130 LY-411575 LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.
M2120 MK-0752 MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells.
M2015 RO4929097 RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling.
M1947 BMS-708163 BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM).
M1746 DAPT DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.