|M3523||YO-01027||YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.|
|M2828||LY900009||LY900009 is a potent Notch inhibitor with IC50 of 0.27 nM.|
|M2827||LY3039478||LY3039478 is a novel and orally bioavailable inhibitor of Notch-1 intracellular domain (N1ICD) cleavage with IC50 of ~1 nM.|
|M2703||FLI-06||FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.|
|M2277||Semagacestat||Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.|
|M2172||LY2811376||LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM.|
|M2130||LY-411575||LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.|
|M2120||MK-0752||MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells.|
|M2015||RO4929097||RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling.|
|M1947||BMS-708163||BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM).|
|M1746||DAPT||DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.|
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