Catalog

Gamma-secretase Gamma-secretase

Inhibitors

Cat.No.	Name	Information
M3523	YO-01027	YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
M2828	LY900009	LY900009 is a potent Notch inhibitor with IC50 of 0.27 nM.
M2827	LY3039478	LY3039478 is a novel and orally bioavailable inhibitor of Notch-1 intracellular domain (N1ICD) cleavage with IC50 of ~1 nM.
M2703	FLI-06	FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
M2277	Semagacestat	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.
M2172	LY2811376	LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM.
M2130	LY-411575	LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.
M2120	MK-0752	MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells.
M2015	RO4929097	RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling.
M1947	BMS-708163	BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM).
M1746	DAPT	DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.