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LY-411575

Cat. No. M2130
LY-411575 Structure
Synonym:

LSN-411575

Size Price Availability Quantity
10mg USD 210 In stock
50mg USD 645 In stock
100mg USD 960 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LY-411575 is a selective, cell permeable gamma-secretase inhibitor with IC50 of 0.082 nM for cell-based γ-secretase. LY-411575 decreased overall thymic cellularity and impaired intrathymic differentiation at the CD4(-)CD8(-)CD44(+)CD25(+) precursor stage. LY-411575 reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Treatment with LY-411575 (LSN-411575) arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 479.48
Formula C26H23F2N3O4
CAS Number 209984-57-6
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.
Busche MA, et al. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5. PMID: 22592800.

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.
Wong GT, et al. J Biol Chem. 2004 Mar 26;279(13):12876-82. PMID: 14709552.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LY-411575, LSN-411575 supplier, Gamma-secretase, inhibitors

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