Free shipping on all orders over $ 500

E1/E2/E3 Enzyme E1/E2/E3 Enzyme

Cat.No.  Name Information
M2969 PYR-41 PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
M31238 M435-1279  M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
M25545 Brigimadlin Brigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor. Brigimadlin serves as an antineoplastic agent.
M20714 NAcM-OPT NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
M14330 TAK-243 TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination.
M14326 Avadomide Avadomide (CC 122) is an orally effective cereblon modulator. avadomide modulates cereblon E3 ligase activity and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Avadomide has antitumor and immunomodulatory activities. CC-122 is more potent in degrading IKZF1 and IKZF3 than lenalidomide and has broader and enhanced antiproliferative activity in ABC- and GCB-DLBCL cell lines.
M14325 BI8622 BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM.
M11295 Mezigdomide (CC-92480) Mezigdomide (CC-92480) is a novel protein reducing agent and cereblon E3 ligase modulator (CELMoD). Mezigdomide has a strong affinity with Cereblon and has anti-myeloma activity.
M9828 2-D08 2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation.
M9634 TAK-981 TAK-981 is a first-in-class SUMO-activating enzyme inhibitor with superior immune activation and antitumor activity.
M8419 PRT4165 PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro.
M6791 Heclin Heclin is a hECT E3 ubiquitin ligase inhibitor.
M6750 Ginkgolic Acid Ginkgolic Acid is a inhibits SUMOylation by binding E1.
M6072 Iberdomide Iberdomide (CC-220) is an orally effective cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 for cereblon binding affinity of approximately 150 nM. Iberdomide (CC-220) binds CRBN with higher affinity than lenalidomide and pomalidomide and has enhanced degradation of IKZF1 and IKZF3 with enhanced degradation.
M4846 CC0651 CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM.
M2892 NSC697923 NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
M52641 TRAF6 peptide TRAF6 peptide is a specific TRAF6-p62 inhibitor.
M50180 LTP001 LTP001 is a SMURF1 antagonist that can be used in studies related to idiopathic pulmonary fibrosis (IPF).
M42345 HECT E3-IN-1 HECT E3-IN-1 is a HECT E3 ligase inhibitor.
M42344 Cbl-b-IN-5 Cbl-b-IN-5 is a Cbl-b inhibitor (IC50=3-10 µM).




Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.