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Iberdomide

Cat. No. M6072
Iberdomide Structure
Synonym:

CC220; CC 220; CC-220

Size Price Availability Quantity
5mg USD 115  USD115 In stock
10mg USD 200  USD200 In stock
25mg USD 400  USD400 In stock
50mg USD 650  USD650 In stock
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Quality Control & Documentation
Biological Activity

In vitro: Lenalidomide and pomalidomide, targeting cereblon, are immunomodulatory drugs that are clinically effective in the treatment of cancer, including newly diagnosed and relapsed multiple myeloma. Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM. In vivo: Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM).

Chemical Information
Molecular Weight 449.5
Formula C25H27N3O5
CAS Number 1323403-33-3
Solubility (25°C) DMSO >100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Grasso EJ, et al. Histochem Cell Biol. Urothelial endocytic vesicle recycling and lysosomal degradative pathway regulated by lipid membrane composition.

[2] Grasso EJ, et al. Cell Biochem Biophys. Differential response of the urothelial V-ATPase activity to the lipid environment.

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Keywords: Iberdomide, CC220; CC 220; CC-220 supplier, E1/E2/E3 Enzyme, inhibitors, activators


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