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Cat. No. M6072
Iberdomide Structure

CC220; CC 220; CC-220

Size Price Availability Quantity
5mg USD 155 In stock
10mg USD 255 In stock
25mg USD 520 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In vitro: Lenalidomide and pomalidomide, targeting cereblon, are immunomodulatory drugs that are clinically effective in the treatment of cancer, including newly diagnosed and relapsed multiple myeloma. Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM. In vivo: Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 449.5
Formula C25H27N3O5
CAS Number 1323403-33-3
Purity >99%
Solubility 30 mg/mL in DMSO
Storage at -20°C

Urothelial endocytic vesicle recycling and lysosomal degradative pathway regulated by lipid membrane composition.
Grasso EJ, et al. Histochem Cell Biol. 2013 Feb;139(2):249-65. PMID: 23064746.

Differential response of the urothelial V-ATPase activity to the lipid environment.
Grasso EJ, et al. Cell Biochem Biophys. 2011 Sep;61(1):157-68. PMID: 21359951.

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Abmole Inhibitor Catalog 2017

Keywords: Iberdomide, CC220; CC 220; CC-220 supplier, inhibitors

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