In vitro: Lenalidomide and pomalidomide, targeting cereblon, are immunomodulatory drugs that are clinically effective in the treatment of cancer, including newly diagnosed and relapsed multiple myeloma. Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM. In vivo: Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM).
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||30 mg/mL in DMSO|
Urothelial endocytic vesicle recycling and lysosomal degradative pathway regulated by lipid membrane composition.
Grasso EJ, et al. Histochem Cell Biol. 2013 Feb;139(2):249-65. PMID: 23064746.
Differential response of the urothelial V-ATPase activity to the lipid environment.
Grasso EJ, et al. Cell Biochem Biophys. 2011 Sep;61(1):157-68. PMID: 21359951.
6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide.
Lanolin is a wax secreted by the sebaceous glands of wool-bearing animals and used widely in the pharmaceutical and cosmetics industries.
Potassium acetate is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties.
5-Phenyl-2,4-pentadienoic acid is used as Synthetic building block, anti-malarial agent.
Methyl 4-hydroxybenzoate is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives.
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