| Cat.No. | Name | Information |
|---|---|---|
| M2969 | PYR-41 | PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. |
| M42345 | HECT E3-IN-1 | HECT E3-IN-1 is a HECT E3 ligase inhibitor. |
| M42344 | Cbl-b-IN-5 | Cbl-b-IN-5 is a Cbl-b inhibitor (IC50=3-10 µM). |
| M42343 | TRAF6 peptide TFA | TRAF6 peptide TFA is a specific TRAF6-p62 inhibitor. |
| M42342 | Skp2 inhibitor 1 | Skp2 inhibitor 1 is a potent and selective Skp2 inhibitor against the Skp2-Cks1 interaction with an IC50 of 2.8 μM. |
| M42341 | Smurf1-IN-1 | Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. |
| M30020 | EN219 | EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination. |
| M29907 | RNF5 inhibitor inh-02 | RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research. |
| M29592 | RB-3 | RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM. |
| M29433 | WS-383 | WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. |
| M29432 | WS-383 free base | WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. |
| M29429 | DI-1859 | DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage. |
| M29426 | DI-591 | DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members. |
| M28978 | BI8626 | BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM. |
| M28241 | BRD5529 | BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC50 value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). |
| M27635 | BC-1382 | BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC50≈ 5 nM).Anti-inflammatory activity. |
| M14331 | TZ9 | TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. |
| M14329 | SMIP004 | SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells. |
| M14328 | NSC232003 | NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. |
| M14327 | DKM 2-93 | DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM. |
| M10899 | VII-31 | VII-31 is a NEDDylation pathway activator that suppresses tumors in vivo and in vitro. VII-31 also induces apoptosis. |
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