Inhibitors
Cat.No. | Name | Information |
---|---|---|
M2052 | Decitabine (5-Aza-2'-deoxycytidine) | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
M10985 | γ-Oryzanol | γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively. |
M10528 | GSK3685032 | GSK3685032 is a potent first-in-class DNMT1-selective inhibitor. |
M10275 | Bobcat339 | Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. |
M8558 | DC_05 | DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation. |
M6056 | Vitamin D2 | Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM. |
M3008 | SGI-1027 | SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B |
M2182 | RG108 | RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM. |
M2052 | Decitabine (5-Aza-2'-deoxycytidine) | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
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