DNA Methyltransferase DNA Methyltransferase

Inhibitors

Cat.No.	Name	Information
M2052	Decitabine (5-Aza-2'-deoxycytidine)	Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes.
M10985	γ-Oryzanol	γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively.
M10528	GSK3685032	GSK3685032 is a potent first-in-class DNMT1-selective inhibitor.
M10275	Bobcat339	Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a.
M8558	DC_05	DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation.
M6056	Vitamin D2	Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.
M3008	SGI-1027	SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B
M2182	RG108	RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM.
M2052	Decitabine (5-Aza-2'-deoxycytidine)	Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes.