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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M2052 | Decitabine (5-Aza-2'-deoxycytidine) | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
| M13816 | Procainamide | Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias. |
| M13815 | GSK-3484862 | GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates global demethylation in murine embryonic stem cells. |
| M13814 | O6BTG-octylglucoside | O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. |
| M13813 | Bobcat339 hydrochloride | Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. |
| M13812 | 5-Methyl-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation. |
| M10985 | γ-Oryzanol | γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively. |
| M10528 | GSK3685032 | GSK3685032 is a potent first-in-class DNMT1-selective inhibitor. |
| M10275 | Bobcat339 | Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. |
| M8558 | DC_05 | DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation. |
| M6056 | Vitamin D2 | Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM. |
| M3008 | SGI-1027 | SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B |
| M2182 | RG108 | RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM. |
| M2052 | Decitabine (5-Aza-2'-deoxycytidine) | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
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