Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||80 mg/mL in Ethanol|
Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.
Suenaga M, et al. Curr Alzheimer Res. 2014;11(8):745-54. PMID: 25212913.
|Related DNA Methyltransferase Products|
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RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM.
Decitabine is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes.
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