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Vitamin D2

Cat. No. M6056
Vitamin D2 Structure
Synonym:

Ergocalciferol

Size Price Availability Quantity
500mg USD 60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 396.65
Formula C28H44O
CAS Number 50-14-6
Purity >99%
Solubility 80 mg/mL in Ethanol
Storage at -20°C
References

Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.
Suenaga M, et al. Curr Alzheimer Res. 2014;11(8):745-54. PMID: 25212913.

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Keywords: Vitamin D2, Ergocalciferol supplier, DNA Methyltransferase, inhibitors

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