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DC_05

Cat. No. M8558
DC_05 Structure
Size Price Availability Quantity
5mg USD 400  USD400 In stock
10mg USD 550  USD550 In stock
25mg USD 780  USD780 In stock
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Quality Control & Documentation
Biological Activity

DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation.

Chemical Information
Molecular Weight 383.49
Formula C25H25N3O
CAS Number 890643-16-0
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Subhrojit Sen, et al. Glycyrrhiza glabra alcoholic root extract ameliorates hyperglycemia, hyperlipidemia, and glycation-induced free iron-mediated oxidative reactions

[2] Amira Orabi, et al. Can Preoperative Characteristics Predict the Outcomes of Laparoscopic Cholecystectomy?

[3] Birgl Erdogan, et al. The Effect of Three Different Methods on Venipuncture Pain and Anxiety in Children: Distraction Cards, Virtual Reality, and Buzzy® (Randomized Controlled Trial)

[4] Felipe A Ribeiro, et al. Ultimate pH effects on dry-aged beef quality

[5] Hamad Algamaiah, et al. Conversion kinetics of rapid photo-polymerized resin composites

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  Catalog
Abmole Inhibitor Catalog




Keywords: DC_05 supplier, DNA Methyltransferase, inhibitors, activators


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