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  Catalog
Abmole Inhibitor Catalog 2017

ALK Anaplastic lymphoma kinase

Inhibitors

Cat.No.  Name Information
M5613 Entrectinib (RXDX-101) Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2.
M5320 Crizotinib hydrochloride Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma.
M5317 Brigatinib Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
M5309 ALK-IN-1 ALK-IN-1 is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR.
M4984 CEP-37440 CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
M4811 CH5424802 HCl CH5424802 HCl is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.
M3975 PF-06463922 PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitorwith Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
M3889 LDN-214117 LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM and >100 fold selectivity for ALK5.
M3781 NVP-TAE684 NVP-TAE684 is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM.
M2859 ML347 ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM.
M2806 LDN-212854 LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.
M2805 LDN-193189 hydrochloride LDN193189 hydrochloride is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, 200-fold selectivity for BMP versus TGF-β.
M2789 K02288 K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
M2201 TSR-011 TSR-011 is a potent, orally available ALK inhibitor.
M2109 AZD3463 AZD3463 is a novel ALK/IGF1R inhibitor with IC50 value of 22 nM.
M2075 LDK378 LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM.
M1950 ASP3026 ASP3026 is a novel and selective inhibitor for the ALK kinase.
M1946 CEP-28122 CEP-28122 is a highly potent and selective orally active ALK inhibitor.
M1942 CH5424802 CH5424802 is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM.
M1932 GSK1838705A GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.
M1873 LDN-193189 LDN-193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3.
M1859 ALK5 Inhibitor II ALK5 Inhibitor is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
M1794 SB431542 SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM).
M1743 X-396 X-396 is a potent and highly specific ALK small molecule tyrosine kinase inhibitor.
M1720 AP26113 AP26113 is a highly potent ALK inhibitor with IC50 of 0.62 nM.


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