Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M9203 | Cytochalasin B | Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. |
| M6896 | Latrunculin A | Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively. |
| M21580 | EG-011 | EG-011 is a first-in-class, potent Wiskott-Aldrich Syndrome Protein (WASP) activator that activates the self-inhibited form of WASP via strong actin polymerization.In addition, EG-011 has selective anti-lymphoma activity. |
| M10349 | Dihydrocytochalasin B | Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B. |
| M7866 | Jasplakinolide | Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. |
| M7728 | Cytochalasin D | Cytochalasin D is a cytopermeable actin polymerization inhibitor derived from fungi, which inhibits g-actin -- Cofilin interaction by binding g-actin. Cytochalasin D can also inhibit the binding of Cofilin to F-actin, reduce the release of exosomes and induce YAP phosphorylation. |
| M7312 | SMIFH2 | SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
| M6612 | CK 869 | Ck-869 is an inhibitor of the actin associated protein 2/3 complex (ARP2/3) with an IC50 value of 7 μM. |
| M6611 | CK 666 | Ck-666 is a cell-permeable inhibitor (IC50=12 μM) of the Arp2/3 complex, which binds to the Arp2/3 complex and stabilizes the inactive state of the complex, preventing the movement of Arp2 and Arp3 subunits into the active filamentous conformation. |
| M2523 | CK-636 | CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
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