Free shipping on all orders over $ 500

Cytochalasin D

Cat. No. M7728
Cytochalasin D Structure
Synonym:

Zygosporin A; NSC 209835

Size Price Availability Quantity
1mg USD 250  USD250 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Cytochalasin D is a cytopermeable actin polymerization inhibitor derived from fungi, which inhibits g-actin -- Cofilin interaction by binding g-actin. Cytochalasin D can also inhibit the binding of Cofilin to F-actin, reduce the release of exosomes and induce YAP phosphorylation.

Chemical Information
Molecular Weight 507.62
Formula C30H37NO6
CAS Number 22144-77-0
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gabor Erdoes, et al. The Dark Side of FIBTEM: Cytochalasin D

[2] William H Leatherwood, et al. Evaluation of zoledronate, cytochalasin-D, and desferrioxamine on osseointegration in an intra-medullary femoral implant model

[3] Qingcheng Liu, et al. Cytochalasin D Promotes Osteogenic Differentiation of MC3T3-E1 Cells via p38-MAPK Signaling Pathway

[4] Feng-Ying Huang, et al. Cytochalasin D, a tropical fungal metabolite, inhibits CT26 tumor growth and angiogenesis

[5] R K Chiang, et al. Cytochalasin D reversibly weakens retinal adhesiveness

Related Actin-Related Protein Products
EG-011

EG-011 is a first-in-class, potent Wiskott-Aldrich Syndrome Protein (WASP) activator that activates the self-inhibited form of WASP via strong actin polymerization.In addition, EG-011 has selective anti-lymphoma activity.

Dihydrocytochalasin B

Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B.

Cytochalasin B

Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin.

Jasplakinolide

Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments.

SMIFH2

SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation.

  Catalog
Abmole Inhibitor Catalog




Keywords: Cytochalasin D, Zygosporin A; NSC 209835 supplier, Actin-Related Protein, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.