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Zonisamide

Cat. No. M6068
Zonisamide Structure
Synonym:

CI-912

Size Price Availability Quantity
200mg USD 90 In stock
500mg USD 140 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 212.23
Formula C8H8N2O3S
CAS Number 68291-97-4
Purity >99%
Solubility 42 mg/mL in DMSO
Storage at -20°C
References

Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.
Murata M, et al. Mov Disord. 2015 Sep;30(10):1343-50. PMID: 26094993.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Zonisamide, CI-912 supplier, Sodium Channel, inhibitors

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