Zofenopril is a long-lasting, lipophilic ACE inhibitor with cardioprotective properties indicated for the treatment of hypertension. Zofenopril is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus. zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR. In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with fewer adverse effects.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling.
Frascarelli S, et al. J Cardiovasc Pharmacol. 2009 Nov;54(5):456-63. PMID: 19738489.
Temperature, pH and agitation rate as dissolution test discriminators of zofenopril calcium tablets.
Lozano R, et al. J Pharm Biomed Anal. 1994 Feb;12(2):173-7. PMID: 8003543.
Sites of first-pass bioactivation (hydrolysis) of orally administered zofenopril calcium in dogs.
Morrison RA, et al. Pharm Res. 1991 Mar;8(3):370-5. PMID: 2052527.
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