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Zofenopril calcium

Cat. No. M3758

Zofenopril calcium Structure

Synonym: SQ26991

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 115 In stock
50mg USD 480 In stock
100mg USD 745 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Zofenopril is a long-lasting, lipophilic ACE inhibitor with cardioprotective properties indicated for the treatment of hypertension. Zofenopril is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus. zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR. In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with fewer adverse effects.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 428.54
Formula C22H22NO4S2
CAS Number 81938-43-4
Purity >99%
Solubility DMSO
Storage at -20°C
References

Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling.
Frascarelli S, et al. J Cardiovasc Pharmacol. 2009 Nov;54(5):456-63. PMID: 19738489.

Temperature, pH and agitation rate as dissolution test discriminators of zofenopril calcium tablets.
Lozano R, et al. J Pharm Biomed Anal. 1994 Feb;12(2):173-7. PMID: 8003543.

Sites of first-pass bioactivation (hydrolysis) of orally administered zofenopril calcium in dogs.
Morrison RA, et al. Pharm Res. 1991 Mar;8(3):370-5. PMID: 2052527.

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  Catalog
Abmole Inhibitor Catalog 2017




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