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ZM 39923 hydrochloride

Cat. No. M3141
ZM 39923 hydrochloride Structure
Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 430 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ZM 39923 is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. ZM39923 inhibits the generation of AICD-FLAG and both Aβ40 and Aβ42 by purified γ-secretase in a concentration-dependent fashion with an approximate IC50 of 20 μM. ZM39923, a Janus kinase inhibitor,is the most potent inhibitors with IC(50) of 10 and 5 nM, respectively.ZM 39923 Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 367.91
Formula C23H25NO.HCl
CAS Number 1021868-92-7
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
Lai TS, et al. Chem Biol. 2008 Sep 22;15(9):969-78. PMID: 18804034.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ZM 39923 hydrochloride supplier, JAK, inhibitors

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