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ZM 323881 hydrochloride

Cat. No. M3140
ZM 323881 hydrochloride Structure
Size Price Availability
10mg USD 120 Out of stock
50mg USD 480 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ZM 323881 is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2. ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro. ZM 323881 (10 nM) abolishes VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in male leopard. ZM 323881 (10 nM) blocks the increase in intensity of the VEGF-R2 band in the lung of male leopard frogs.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 411.86
Formula C22H18FN3O2.HCl
CAS Number 193000-39-4
Purity >98%
Solubility DMSO
Storage at -20°C
References

ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity.
Whittles CE, et al. Microcirculation. 2002 Dec;9(6):513-22. PMID: 12483548.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ZM 323881 hydrochloride supplier, VEGFR/PDGFR, inhibitors

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