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Ligustilide

Cat. No. M4430
Ligustilide Structure
Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 305  USD305 In stock
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Quality Control & Documentation
Biological Activity

Ligustilide is a bioactive phthalate derivative isolated from Angelica sinensis and Ligusticum chuanxiong. Ligustilide has neuroprotective, anticancer, anti-inflammatory and vasodilatation effects.
*The compound is unstable in solutions, freshly prepared is recommended


Chemical Information
Molecular Weight 190.24
Formula C12H14O2
CAS Number 4431-01-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yiqiu Cao, et al. Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis

[2] Chengqiang Wang, et al. Z-Ligustilide Selectively Targets AML by Restoring Nuclear Receptors Nur77 and NOR-1-mediated Apoptosis and Differentiation

[3] Bing Yang, et al. Z-Ligustilide Ameliorates Diabetic Rat Retinal Dysfunction Through Anti-Apoptosis and an Antioxidation Pathway

[4] Qingxuan Xie, et al. Z-ligustilide: A review of its pharmacokinetics and pharmacology

[5] Yang Yi, et al. Z-Ligustilide Exerted Hormetic Effect on Growth and Detoxification Enzymes of Spodoptera litura Larvae

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