Ligustilide

Cat. No. M4430

Size	Price	Availability	Quantity
5mg	USD 200 USD200	In stock
10mg	USD 305 USD305	In stock

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Quality Control

Current batch:
Purity >98%
COA
MSDS

Product Information

Biological Activity

Ligustilide is a bioactive phthalate derivative isolated from Angelica sinensis and Ligusticum chuanxiong. Ligustilide has neuroprotective, anticancer, anti-inflammatory and vasodilatation effects.
*The compound is unstable in solutions, freshly prepared is recommended

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

Molecular Weight	190.24
Formula	C12H14O2
CAS Number	4431-01-0
Purity	>98%

Solubility	DMSO ≥ 60 mg/mL
Storage	-20°C , protect from light , dry , sealed

References

[1] Yiqiu Cao, et al. Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis

[2] Chengqiang Wang, et al. Z-Ligustilide Selectively Targets AML by Restoring Nuclear Receptors Nur77 and NOR-1-mediated Apoptosis and Differentiation

[3] Bing Yang, et al. Z-Ligustilide Ameliorates Diabetic Rat Retinal Dysfunction Through Anti-Apoptosis and an Antioxidation Pathway

[4] Qingxuan Xie, et al. Z-ligustilide: A review of its pharmacokinetics and pharmacology

[5] Yang Yi, et al. Z-Ligustilide Exerted Hormetic Effect on Growth and Detoxification Enzymes of Spodoptera litura Larvae

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Catalog

Signaling Pathways

Product Type

Ligustilide

Quality Control

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Chemical Information

References

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