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Ligustilide

Cat. No. M4430
Ligustilide Structure
Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 305  USD305 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ligustilide is a bioactive phthalate derivative isolated from Angelica sinensis and Ligusticum chuanxiong. Ligustilide has neuroprotective, anticancer, anti-inflammatory and vasodilatation effects.
*The compound is unstable in solutions, freshly prepared is recommended


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 190.24
Formula C12H14O2
CAS Number 4431-01-0
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage -20°C , protect from light , dry , sealed
References

[1] Yiqiu Cao, et al. Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis

[2] Chengqiang Wang, et al. Z-Ligustilide Selectively Targets AML by Restoring Nuclear Receptors Nur77 and NOR-1-mediated Apoptosis and Differentiation

[3] Bing Yang, et al. Z-Ligustilide Ameliorates Diabetic Rat Retinal Dysfunction Through Anti-Apoptosis and an Antioxidation Pathway

[4] Qingxuan Xie, et al. Z-ligustilide: A review of its pharmacokinetics and pharmacology

[5] Yang Yi, et al. Z-Ligustilide Exerted Hormetic Effect on Growth and Detoxification Enzymes of Spodoptera litura Larvae

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