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Yohimbine

Cat. No. M13902
Yohimbine Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 354.44
Formula
CAS Number 146-48-5
Purity >99%
Solubility DMSO 5 mg/mL
Storage at -20°C
References

[1] Guanqun Zhan, et al. Cytotoxic Yohimbine-Type Alkaloids from the Leaves of Rauvolfia vomitoria

[2] Nevio Cimolai, et al. Yohimbine use for physical enhancement and its potential toxicity

[3] Sergej M Ostojic. Yohimbine: the effects on body composition and exercise performance in soccer players

[4] S W Tam, et al. Yohimbine: a clinical review

[5] M Shannon, et al. Yohimbine

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