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YM155

Cat. No. M2342

YM155 Structure

Synonym: Sepantronium bromide

Size Price Availability Quantity
10mg USD 85 In stock
50mg USD 300 In stock
100mg USD 460 In stock
200mg USD 680 In stock
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Quality Control
Biological Activity

YM155 (Sepantronium bromide) is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. YM155 also completely inhibited the growth of orthotopically xenografted PC-3 tumors. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM. YM155 is highly distributed to tumors and at concentrations approximately 20-fold higher than those in plasma. YM155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 443.29
Formula C20H19BrN4O3
CAS Number 781661-94-7
Purity >99%
Solubility DMSO 50 mg/mL
Water 80 mg/mL
Storage at -20°C
References

Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines.
Iwasa T, et al. Clin Cancer Res. 2008 Oct 15;14(20):6496-504. PMID: 18927289.

YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.
Nakahara T, et al. Cancer Res. 2007 Sep 1;67(17):8014-21. PMID: 17804712.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: YM155, Sepantronium bromide supplier, Survivin, inhibitors

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