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YL-0919

Cat. No. M9252
YL-0919 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 180 In stock
5mg USD 235 In stock
10mg USD 345 In stock
50mg USD 1070 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

YL-0919 inhibits the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells with IC50 values of 1.78±0.34 nM and 1.93±0.18 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 334.84
Formula C18H23ClN2O2
CAS Number 1339058-04-6
Purity >98%
Solubility DMSO: ≥ 20 mg/mL
Storage at -20°C
References

The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor.
Qin JJ, et al. Neurosci Lett. 2014 Oct 17;582:104-8. PMID: 25220701.

Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist.
Chen HX, et al. PLoS One. 2013 Dec 18;8(12):e83271. PMID: 24367588.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: YL-0919 supplier, 5-HT Receptor, inhibitors

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