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Xanthoxylin

Cat. No. M17299
Xanthoxylin Structure
Synonym:

Xanthoxyline

Size Price Availability Quantity
100mg USD 60  USD60 In stock
250mg USD 105  USD105 In stock
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Quality Control & Documentation
Biological Activity

Xanthoxylin has antifungal and antispasmodic activities. Xanthoxylin is isolated from Zanthoxylum simulans.

Chemical Information
Molecular Weight 196.2
Formula C10H12O4
CAS Number 90-24-4
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sukhvir Kaur, et al. Bioorg Chem. Design, molecular Docking, synthesis and evaluation of xanthoxylin hybrids as dual inhibitors of IL-6 and acetylcholinesterase for Alzheimer's disease

[2] Carmen Rossini, et al. J Chem Ecol. When a Tritrophic Interaction Goes Wrong to the Third Level: Xanthoxylin From Trees Causes the Honeybee Larval Mortality in Colonies Affected by the River Disease

[3] Yuan-Hui Wang, et al. PLoS One. Variations in compositions and antioxidant activities of essential oils from leaves of Luodian Blumea balsamifera from different harvest times in China

[4] Christian Dank, et al. Molecules. A Many-Faced Alkaloid: Polymorphism of (-)-Monophyllidin

[5] Nanashara C de Carvalho, et al. Cell Death Dis. A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway

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