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Wighteone

Cat. No. M16798
Wighteone Structure
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Biological Activity

Wighteone

Chemical Information
CAS Number 51225-30-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hardo Suzy Donfack Chouna, et al. Parasitol Res. Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity

[2] Peiyuan Sun, et al. J Cancer. Wighteone exhibits an antitumor effect against EGFR L858R/T790M mutation non-small cell lung cancer

[3] Jinyue Liu, et al. Plant Cell Physiol. Genistein-Specific G6DT Gene for the Inducible Production of Wighteone in Lotus japonicus

[4] Zhong-Wei Cao, et al. Oncol Lett. HSP90 expression and its association with wighteone metabolite response in HER2-positive breast cancer cells

[5] Hongying Yin, et al. Biotechnol Lett. Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent

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