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Voriconazole

Cat. No. M3953
Voriconazole Structure
Synonym:

UK-109496

Size Price Availability Quantity
10mM*1mL in DMSO USD 35  USD35 In stock
10mg USD 30  USD30 In stock
25mg USD 50  USD50 In stock
50mg USD 65  USD65 In stock
100mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Voriconazole (UK-109496) is an antifungal compound used to treat severe fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase, leading to ergosterol depletion in fungal cell membranes. Voriconazole is widely metabolized in the liver by the cytochrome P450 enzyme, mainly CYP2C9 and CYP3A4. 

Chemical Information
Molecular Weight 349.32
Formula C16H14F3N5O
CAS Number 137234-62-9
Solubility (25°C) DMSO 60 mg/mL
Ethanol 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Diekema DJ, et al. J Clin Microbiol. Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.

[2] Marco F, et al. Antimicrob Agents Chemother. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp.

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Keywords: Voriconazole, UK-109496 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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