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Voriconazole

Cat. No. M3953
Voriconazole Structure
Synonym:

UK-109496

Size Price Availability Quantity
10mM*1mL USD 110  USD110 In stock
50mg USD 100  USD100 In stock
100mg USD 130  USD130 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Voriconazole is an antifungal compound used to treat severe fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase, leading to ergosterol depletion in fungal cell membranes. Voriconazole is widely metabolized in the liver by the cytochrome P450 enzyme, mainly CYP2C9 and CYP3A4. Voriconazole can also cause side effects such as impaired vision, skin rashes and elevated liver enzyme levels.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 349.32
Formula C16H14F3N5O
CAS Number 137234-62-9
Purity >98%
Solubility DMSO 100mg/ml
Ethanol 100mg/ml
Storage at -20°C
References

[1] Diekema DJ, et al. J Clin Microbiol. Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.

[2] Marco F, et al. Antimicrob Agents Chemother. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp.

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Keywords: Voriconazole, UK-109496 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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