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Villosin

Cat. No. M16538
Villosin Structure
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Biological Activity

Villosin

Chemical Information
CAS Number 160598-92-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wilson R Tavares, et al. Medicines (Basel). Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

[2] Hai-Jun Hu, et al. J Nat Prod. Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities

[3] Linzhen Li, et al. Nat Prod Commun. Abietane diterpenoids from Clerodendrum trichotomum and correction of NMR data of Villosin C and B

[4] Rameshwar Verma, et al. Pharmacogn Rev. Rubus fruticosus (blackberry) use as an herbal medicine

[5] Iyared Kumrit, et al. Phytother Res. Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells

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