Free shipping on all orders over $ 500

Enmein

Cat. No. M16544
Enmein Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Enmein

Chemical Information
CAS Number 3776-39-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cheng-Wei Lu, et al. Int J Mol Sci. Enmein Decreases Synaptic Glutamate Release and Protects against Kainic Acid-Induced Brain Injury in Rats

[2] Xu Hu, et al. Eur J Med Chem. Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation

[3] Fanxing Xu, et al. Bioorg Chem. Hydrogen sulfide releasing enmein-type diterpenoid derivatives as apoptosis inducers through mitochondria-related pathways

[4] Haonan Li, et al. Arch Pharm Res. Bioactive enmein-type 6,7-seco-ent-kaurane diterpenoids: natural products, synthetic derivatives and apoptosis related mechanism

[5] Jin Yang, et al. J Nat Prod. Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys

Related Diterpenoids Products
Itol A

Itol A

Phytol

Phytol

Taxin B

Taxin B

Quassin

Quassin

Totarol

Totarol

  Catalog
Abmole Inhibitor Catalog




Keywords: Enmein supplier, Diterpenoids, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.