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Vestitol

Cat. No. M16818
Vestitol Structure
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Quality Control & Documentation
Biological Activity

Vestitol

Chemical Information
CAS Number 35878-41-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bruno Bueno-Silva, et al. Pharmaceuticals (Basel). Anti-Inflammatory Effects of (3 S)-Vestitol on Peritoneal Macrophages

[2] Bruno Bueno-Silva, et al. Int Immunopharmacol. Vestitol drives LPS-activated macrophages into M2 phenotype through modulation of NF-κB pathway

[3] Marcelo Franchin, et al. J Nat Prod. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action

[4] Bruno Bueno-Silva, et al. J Agric Food Chem. Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis

[5] Hiroaki Ueda, et al. Biosci Biotechnol Biochem. Vestitol as a chemical barrier against intrusion of parasitic plant Striga hermonthica into Lotus japonicus roots

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