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Venlafaxine HCl

Cat. No. M6050
Venlafaxine HCl Structure
Synonym:

Wy 45030 hydrochloride

Size Price Availability Quantity
50mg USD 155 In stock
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Quality Control
Biological Activity

Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 313.86
Formula C17H27NO2·HCl
CAS Number 99300-78-4
Purity 99.25%
Solubility 55 mg/mL in DMSO
Storage at -20°C
References

Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique.
Khanfar M, et al. Pharm Dev Technol. 2014 Feb;19(1):103-15. PMID: 23347382.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Venlafaxine HCl, Wy 45030 hydrochloride supplier, 5-HT Receptor, inhibitors

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