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Vedolizumab

Cat. No. M1618
Vedolizumab Structure
Synonym:

MLN-02; LDP-02; MLN0002

Size Price Availability Quantity
2mg USD 530 In stock
5mg USD 740 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vedolizumab is a monoclonal antibody binds to integrin α4β7. Vedolizumab blocks the α4β7 integrin, results in gut-selective anti-inflammatory activity. Vedolizumab binds to memory CD4(+) T and B lymphocytes with subnanomolar potency (EC(50) = 0.3-0.4 nM). Vedolizumab also binds to eosinophils at high levels, and to naive T-helper lymphocytes, naive and memory cytotoxic T lymphocytes, B lymphocytes, natural killer cells, and basophils at lower levels. Vedolizumab selectively inhibits adhesion of alpha(4)beta(7)-expressing cells to mucosal addressin cell adhesion molecule 1 (median inhibition concentration [IC(50)] = 0.02-0.06 microg/ml) and fibronectin (IC(50) = 0.02 microg/ml), but not vascular cell adhesion molecule 1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 146834.53
Formula C6528H10072N1732O2042S42
CAS Number 943609-66-3
Purity >98%
Solubility
Storage -80°C for long term
References

Exclusive antagonism of the α4 β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates.
Fedyk ER, et al. Inflamm Bowel Dis. 2012 Nov;18(11):2107-19. PMID: 22419649.

The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases.
Soler D, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):864-75. PMID: 19509315.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vedolizumab, MLN-02; LDP-02; MLN0002 supplier, Integrin, inhibitors

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