Cat.No. | Name | Information |
---|---|---|
M9173 | Cilengitide trifluoroacetate | Cilengitide is a potent integrin inhibitor for αvβ3 and αvβ5 receptor with IC50 of 4.1 nM, 79 nM in cell-free assays respectively. |
M8975 | CWHM-12 | CWHM-12 is a potent inhibitor of αV integrins with IC50 values of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1, respectively. |
M2042 | Cilengitide | Cilengitide (EMD 121974, NSC 707544) is a selective inhibitor of αvβ3 integrin and αvβ5 integrin with IC50 of 1 nM and 140 nM, respectively. |
M45151 | Lifitegrast sodium | Lifitegrast sodium is a potent integrin antagonist that blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen (LFA-1) and interrupts the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits the attachment of Jurkat T cells to ICAM-1 with an IC50 of 2.98 nM.May be useful in studies related to dry eye. |
M45137 | Fuzapladib | Fuzapladib is a leukocyte adhesion molecule and an orally active inhibitor of leukocyte function-associated antigen type 1 (LFA-1) activation.Fuzapladib is also a phospholipase A2 (PLA2) inhibitor, which exerts anti-inflammatory activity by inhibiting the migration of leukocytes to sites of inflammation. |
M40619 | Dentonin acetate | Dentonin acetate is an amino acid peptide derived from matrix extracellular phosphoglycoprotein (MEPE) and has the ability to promote the proliferation of dental pulp stem cells (DPSCs), which can be used in studies related to endodontic restoration and osteoarthritis (OA). |
M29565 | Bexotegrast | Bexotegrast is a potent inhibitor of ανβ6 integrin. Bexotegrast can be used for researching fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). |
M25212 | Rovelizumab | Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke. |
M19984 | ILK-IN-3 | ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with anti-tumor activity. |
M13756 | RGD Trifluoroacetate | RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins. |
M13755 | iRGD peptide | iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. |
M13754 | OSU-T315 | OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). |
M13752 | BIO-1211 | BIO-1211 is a highly selective and orally active α4β1 (VLA-4) inhibitor, with IC50 values of 4 nM and 2 μM for α4β1 and α4β7, respectively. |
M13751 | Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. |
M13750 | α2β1 Integrin Ligand Peptide TFA | α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors. |
M11424 | Carotegrast methyl | Carotegrast Methyl (AJM300) is an orally effective and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast Methyl, is a specific dual α4β1/α4β7 integrin antagonist. Carotegrast Methyl prevents colitis in mice. |
M11158 | Cyclo(-RGDfK) TFA | Cyclo(-RGDfK) TFA is a potent, selective integrin αvβ3 INHIBITORS, THEIR IC50 The value is 0.94 nM. Cyclo(-RGDfK) TFA specifically targets tumor microvascular and cancer cells by binding to αvβ3 integrins on the cell surface. |
M10876 | Pyrintegrin | Pyrintegrin is a beta1 integrin (β1-integrin) agonist and a 2,4-dihydrated pyrimidine that promotes embryonic stem cell survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte protector and has a powerful lipolyogenic effect. |
M10730 | GRGDSP TFA | GRGDSP (TFA) is an integrin inhibitor. |
M10729 | TR-14035 | TR-14035 is an orally active α4b7/a4b1 integrins (a4b7/a4b1 integrindual inhibitors, for α4b7 和 a4b1 function IC50 The values are 7 nM and 87 nM, respectively. TR-14035 can be used for the study of inflammatory and autoimmune diseases. |
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