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Vazegepant hydrochloride

Cat. No. M10372
Vazegepant hydrochloride Structure
Synonym:

Zavegepant, BHV-3500 hydrochloride

Size Price Availability Quantity
2mg USD 150  USD150 In stock
5mg USD 280  USD280 In stock
10mg USD 430  USD430 In stock
25mg USD 750  USD750 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 675.26
Formula C36H47ClN8O3
CAS Number 1414976-20-7
Purity >98%
Solubility Water 50 mg/mL
DMSO 50 mg/mL
Storage at -20°C
References

[1] David Moreno-Ajona, et al. Curr Opin Neurol. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?

[2] Gene M Dubowchik, et al. J Med Chem. Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success

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Keywords: Vazegepant hydrochloride, Zavegepant, BHV-3500 hydrochloride supplier, CGRP Receptor, inhibitors

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