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UNC0224

Cat. No. M3101
UNC0224 Structure
Size Price Availability Quantity
10mg USD 162  USD162 In stock
50mg USD 720  USD720 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

UNC0224 is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP with IC50 of 15 nM and 20 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 485.67
Formula C26H43N7O2
CAS Number 1197196-48-7
Purity >98%
Solubility DMSO 100 mM
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: UNC0224 supplier, Histone Methyltransferase, inhibitors

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