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Tyrphostin AG528

Cat. No. M9722
Tyrphostin AG528 Structure
Synonym:

Tyrphostin B66; AG-528

Size Price Availability
25mg USD 155  USD155 4-7 Days
50mg USD 270  USD270 4-7 Days
100mg USD 480  USD480 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tyrphostin AG528 (Tyrphostin B66) is an inhibitor of EGFR and ErbB2 with IC50 values of 4.9 and 2.1 μM, respectively. The natural bond orbital (NBO) analysis suggested that the molecule Tyrphostin AG528 as an electron donor and the CNT(6,6-6) nanotube play the role of an electron acceptor at the complex CNT(6,6-6)/Tyrphostin AG528.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 306.32
Formula C18H14N2O3
CAS Number 133550-49-9
Purity >98%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Masoome Sheikhi, et al. Curr Mol Med. Investigation of Adsorption Tyrphostin AG528 Anticancer Drvg Upon the CNT(6,6-6) Nanotube: A DFT Study

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Keywords: Tyrphostin AG528, Tyrphostin B66; AG-528 supplier, EGFR/HER2, inhibitors

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